Prediction of Sennosides from Senna Leaves (Cassia angustifolia) for Management of Constipation in Hemodialysis Patients

Abstract

Constipation is a common issue among hemodialysis patients, significantly impacting their quality of life. Factors such as a low-fiber diet and fluid restrictions contribute to the worsening of this condition. Herbal laxatives, particularly senna leaves (Cassia angustifolia), which contain sennosides, have shown potential as a safe and effective alternative for managing constipation. This study utilized an in silico approach to predict the biological activity of sennosides using PASS Online. The results indicate that sennosides have a high probability of functioning as a laxative, with an activity probability value (Pa) of 0.921 and an inactivity probability (Pi) of 0.001. These values suggest a strong potential for laxative activity. Additionally, the pharmacokinetic predictions show that sennosides have favorable clearance rates, allowing for efficient elimination from the body and reducing the risk of drug accumulation. However, dose adjustments remain necessary based on the patient’s residual renal function. The findings from this in silico study provide valuable insights into the biological interactions and cost efficiency of sennosides as a natural laxative, supporting their potential use in hemodialysis patients suffering from constipation.