Prediction of Lycorine from Lily Flower (Lilium spp.) as MAP Kinase Stimulant for Cancer Therapy

Abstract

Lycorine, an alkaloid compound found in lily flowers (Lilium spp.), has been predicted to have activity as a stimulant of the MAP kinase pathway based on in silico analysis.. Lycorine molecular data was obtained from PubChem database in SMILES format and analyzed using Prediction of Activity Spectra for Substances (PASS) platform available at Way2Drug. The analysis showed that lycorine has an activity probability (Pa) of 0.760 and a very low inactivity probability (Pi) of 0.004. The high Pa value indicates a high likelihood that lycorine can stimulate the MAP kinase pathway, which plays an important role in the regulation of cancer cell growth and apoptosis. With this potential, lycorine may contribute to inducing pro-apoptotic mechanisms as well as inhibiting cancer cell proliferation through modulating the MAP kinase pathway. These predictive results provide a strong scientific basis for further exploration of lycorine as a candidate cancer therapy.