Prediction of alpha-Mangostin from Mangosteen (Garcinia mangostana L.) for Anti-Helicobacter Pylori and Basic Education Learning

Abstract

Mangostin, a xanthone compound derived from Garcinia mangostana L., has been widely studied for its pharmacological properties, including antibacterial activity. This study aimed to predict the anti-Helicobacter pylori potential of mangostin using in silico analysis. The pharmacological activity prediction, performed using Way2Drug PASS Online, demonstrated a high probability of activity (Pa = 0.781) and a low probability of inactivity (Pi = 0.002), indicating a strong likelihood that mangostin exhibits antibacterial effects against H. pylori. These results suggest that mangostin may act through multiple mechanisms, such as inhibiting essential bacterial enzymes and disrupting membrane integrity. The findings support further investigations through molecular docking, molecular dynamics simulations, and experimental validation (in vitro and in vivo) to confirm its efficacy and safety. Given the increasing antibiotic resistance of H. pylori, mangostin represents a promising natural alternative for future drug development.