The Potential of Caffeine in Coffee (Coffea arabica L.) as a Cyclic GMP Phosphodiesterase Inhibitor for Erectile Dysfunction Disease and Basic Education Learning

Abstract

Cyclic GMP phosphodiesterase (PDE) inhibitors play a critical role in conditions like erectile dysfunction (ED) by preventing the breakdown of cGMP, which promotes smooth muscle relaxation and vasodilation. This study evaluates the activity and inhibition potency of a compound acting as a PDE inhibitor. The compound shows a moderate activity level (pa value of 0.648), suggesting a moderate ability to inhibit PDE. However, its inhibition potency (pi value of 0.002) indicates strong effectiveness at low concentrations. These values suggest that the compound can significantly elevate cGMP levels, potentially improving blood flow and muscle relaxation. This could make it a promising alternative to traditional PDE5 inhibitors such as sildenafil for ED treatment. The compound’s natural origin offers additional benefits, including reduced side effects and cost. However, further research is needed to explore its therapeutic potential, optimal dosages, and long-term safety in clinical applications